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The effect is promising, but again, it came from a very small sample, so read it as "deserves more research" rather than "proven for everyone." Several small clinical trials on oral glutathione, some using doses similar to this product, have shown modest reductions in melanin index and improvements in skin brightness over 4 to 12 weeks

It had been shown that protein kinase R (PKR) was activated in the later stages of HSV-1 infection enhancing phosphorylation of eIF-2 (Chou et al., 1995) and inducing phosphorylation of endoplasmic reticulum resident kinase (pERK) (Cheng et al., 2005), thereby inhibiting protein synthesis (Poppers et al., 2000)