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designed a nanoplatform (AS_LIG@PPGC NPs) co-encapsulating astragaloside IV (AS) and ligustrazine (LIG), which demonstrated potent anti-fibrotic efficacy through dual-pathway suppression of NOX4-mediated ROS/p38 MAPK and NLRP3 signaling, reducing ROS generation while disrupting the self-amplifying loop between NOX4 activation and inflammasome formation (Zheng et al., 2024)

10 Glutathione-triggered sensing and imaging strategies Glutathione (GSH) is highly abundant in tumors and serves as a valuable target for redox-responsive diagnostics

Furthermore, ethosomes enable a synergistic approach that combines plant extracts with conventional chemical drugs, resulting in extended therapeutic activity, reduced side effects, and minimized drug resistance [134, 135]

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Establishes tolerance baseline and detects any injection-site reactivity