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attributable to the transcriptional repression and functional impairment of the glycolytic enzyme phosphofructokinase ( + T cells deviate from a normal differentiation pattern and make a commitment to become a pro-inflammatory effector cell

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In a telemeterized NHP study, RM-718 caused no significant changes to mean systolic blood pressure and mean diastolic blood pressure over the course of a 3-day SC infusion (1 and 5 mg/kg) compared to 2 days pre-dose (130)

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