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Chronic venous disease

This overabundance of lactate is associated with a worsened disease state, potentially by creating a pro-inflammatory microenvironment, disrupting the balance of short-chain fatty acid production, and directly impairing epithelial barrier function [130]

By updating the terminology, we aim to set a cleaner, more responsible standard for the industry

Skin biopsy findings Four probands out of seven and one affected relative had skin biopsies examined with electron microscopy (EM) in this cohort

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