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Moreover, cerium dioxide (CeO 2 ) nanoparticles can significantly reduce the CD4+ PD-1 high T cells driving malignancy and activate CD8 + T cells to restore their powerful anti-tumor function, significantly improving survival rates (156)

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Given BPC-157's apparent pro-angiogenic effects (VEGF upregulation), a theoretical concern about promotion of tumor vascularization exists and has not been ruled out by long-term animal studies

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