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Research on lasting side effects is limited, so its long-term safety and overall health impact remain unclear

Sleep quality can suffer due to apnea, insomnia, narcolepsy, and restless leg syndrome

News: Excess Vitamin B12 May Be Deadly

surrogate endpoints (weight, HbA1c) are not hard outcomes

Thus, appropriate therapy for PCOS becomes necessary in order to induce ovulatory cycles and fertility ( Metformin is the most commonly used insulin-sensitizing drug to treat PCOS thanks to its ability to increase insulin sensitivity, reduce hepatic gluconeogenesis, as well as to inhibit hepatic uptake of lactate and alanine, and to increase the conversion of pyruvate to alanine