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78 The half-life of PEG-loxenatide is approximately 1 week

Providers routinely encounter patients who experience severe gastrointestinal intolerance, metabolic adaptation, or frustrating weight loss plateaus that render these first-line therapies insufficient

Or, in Garoppolos case, just after the Super Bowl

Clinical trials with drugs that are already actively used in the clinic have several advantages, because drug repurposing can undergo a fast track regarding regulations [265]