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Associated with an increased risk for cardiovascular disease and high mortality rates, DN is the leading kidney disease worldwide

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At the heart of SFNs anti-CSC activity lies its coordinated interference with Wnt/-catenin, Notch, and Hedgehog signaling - three evolutionarily conserved pathways that frequently become dysregulated in CSCs

Mammalian PK has four isoforms with distinct tissue distributions, PKM1 is predominantly expressed in normal adult cells favoring oxidative phosphorylation, while PKM2 is highly expressed in rapidly proliferating tumor and non-malignant cells, favoring glycolysis ( Lactate dehydrogenase (LDH) has gained increasing attention for its significance in cancer

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