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investigated the production of TMAO in the plasma and the urine by feeding patients an eight-ounce steak followed by a capsule of 250 mg heavy isotope-labelled L-carnitine [86]
Abnormal ratios, reflecting impaired carnitine status and/or homeostasis, have been reported in plasma of infants and children with inborn errors of metabolism [93, 94], children with autism spectrum disorder [95], animal models of autism [96] and in brain tissue after OGD in vitro [54]
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