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Berberine side effects are predominantly gastrointestinal and may include: Diarrhoea, constipation, or abdominal discomfort Nausea and flatulence Cramping or bloating These effects are typically dose-dependent and may be minimised by starting with lower doses and taking berberine with meals

Other diagnoses include genetic mutations, chromosomopathies, tuberous sclerosis, polymicrogyria, cerebral infarction, and developmental speech disorders

And some people have genetic variants (like CBS, SUOX, or MTHFR) that affect how well they metabolize and excrete sulfur compounds, meaning more gets pushed out through the skin

American Journal of Physiology-Gastrointestinal and Liver Physiology

3.8.4 Ferroptosis Ferroptosis refers to a specific PCD paradigm resulting from unrestrained lipid peroxidation (128)