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For example, oxidative stress triggers dissociation of the Trx:ASK1 complex by oxidizing thioredoxin, resulting in the activation of ASK1 (Tobiume et al ., 2002)

doi: 10.1124/jpet.111.183004

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In a study involving more than 10,000 elderly individuals, long-term, high-dose NSAID therapy was associated with a significantly increased risk of progression of chronic kidney disease (Gooch 2007)