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In one subject on daily furosemide therapy, the dose was increased after wk 2 of the dosing period and the previously borderline renal insufficiency worsened slightly (creatinine rose from 119 mol/L to 159 mol/L)

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Discussion The chemical cross-linking experiments indicate that the cell-surface Met dimerization triggered by both the dimeric macrocycles and HGF showed bell-shaped dose-dependent profiles (Fig

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