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During bacterial or virus infection of the respiratory tract, natural killer cells (NK cells) and DCs of lung tissue secrete IL-13 to activate the signal transducer and activator of transcription (STAT) 6 pathway, which leads to goblet cell hyperplasia, smooth muscle hyper-responsiveness, and airway remodeling (Pritchard et al., 2016)

The particle pollution of tobacco smoke is best captured by a HEPA or HyperHEPA filter because these filters have the best filtration efficiency without obstructing the airflow much