Source: Reduced Expression of MYC Increases Longevity and Enhances Healthspan (2015) Claim 4: GHK-Cu improves cognitive decline and modulates neuroinflammation
Three things make PDRN a strong alternative for users disappointed by copper peptides: It signals regeneration through a different pathway, so it does not produce the same inflammatory adjustment phase that drives the copper uglies It has fewer documented interactions with other actives, which makes it easier to fit into an existing routine It is generally well tolerated even by sensitive skin, and pregnancy precautions are less restrictive (though pregnant or breastfeeding users should still consult a doctor before adding any new active) The people who tend to do well on PDRN after a bad copper peptide experience usually fit one of three profiles: sensitive-skin users who could never tolerate the copper uglies, users who want regenerative benefits without managing strict layering rules, and users whose primary concern is repair and resilience rather than aggressive remodelling
Glutathione S-transferases: the first enzymatic step in mercapturic acid formation
Le GHK-Cu est photostable et n'est pas photosensibilisant, ce qui le rend adapt une utilisation matinale (toujours sous protection solaire)
The latter is better, but we recommend methylcobalamin, as it includes a methyl group and directly aids in lowering homocysteine levels and in fixing nerve damage, two issues often faced by pernicious anemia and B12 deficiency patients
