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For decades, GPX typically uses glutathione (GSH) as a reducing agent in catalyzing the reduction of H 2 O 2 or organic hydrogen peroxide to water or corresponding alcohols, respectively (Brigelius-Floh and Maiorino, 2013)

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(70) evaluated BMI changes in 150 children with CD over a median of 4.4 years on GFD, compared to healthy controls, showing that although CD children typically present with lower BMI at diagnosis (reflective of malnutrition or underweight status) GFD introduction leads to BMI normalization and a reduction in the proportion of underweight individuals, with only minimal increases in overweight or obese categories