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Met-mediated AMPK activation and inhibition of mTOR activity regulate autophagy flux, inhibit NF-B signal transduction and production of inflammatory cytokines, and reduce inflammation during experimentally induced arthritis [145, 146]

designed a US-triggered MnWO X nanosystem modified with PEG (termed MnWO X -PEG) to endow the capability of GSH-enhanced ROS ( 1 O 2 and OH) production for killing malignant tumors (Figure 6D) ( X -PEG exhibited significantly time-dependent GSH consumption capacity through reducing W 6+ to W 5+ (Figure 6E), cooperating with increased ROS to achieve a powerful inhibition effect on tumors (Figure 6F)