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Exercise and Sport Sciences Reviews, 24(1), 53-77

Chen F, Tang H, Lin J, Xiang L, Lu Y, Kang R et al

VDAC2 is an important component of the mitochondrial apoptotic signaling cascade [203] and is activated by SNO [204]

After the macrophages ingest MSU through the phagocytic pathway, NLRP3 inflammasome assembly and activation are triggered, and the generated complex consists of NLRP3, the adaptor protein apoptosis-related cyclin-like protein (ASC), and caspase-1 (53)

This review will synthesize the current understanding of Ers role in EAOC, repositioning it not as a primary driver, but as a critical modulator that synergizes with the established genetic landscape of Type I tumors