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Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice

High-dose cyanocobalamin leads to accumulation of cyanide in patients with renal failure

doi: 10.3322/caac.21871 5 AgarwalAGuptaSSharmaRK

(Heffernan et al., Endocrinology, 2001) Early human trials: promising but modest Six Phase I/II human clinical trials were conducted, enrolling roughly 900 participants total