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He had never been the type to be mired down in superficiality and dubious dichotomies, so he never cared whether this misuse led to oxidative stress or reductive stress , nor did he care whether free radicals had instigated the misuse of these electrons or if the culprits were at their core truly radical-free

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Furthermore, the dopamine metabolism process inherent to vulnerable nigrostriatal neurons intrinsically generates ROS, further damaging mitochondrial complex I and proteasome function, creating a vicious cycle of oxidative stress and neurodegeneration [336]