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Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology

In contrast to LPS stimulation, known to increase intracellular ROS and thus increase the intracellular GSH/GSSG ratio without changing total glutathione levels ( Supplementary Figure 3 ) (37), BDG exposure increases both the GSH/GSSG ratio and the total amount of intracellular GSH ( Figure 4D )

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Thus, a comprehensive understanding of PD pathogenesis requires integrating this multicellular network, in which neuronal vulnerability is shaped by dysregulated interactions among neurons, glia, vascular cells, and peripheral immune components

BachPHayashiKMilloyMNosovaEKerrTWoodEet alCharacterising the increasing prevalence of crystal methamphetamine use in Vancouver, Canada, from 2006-2017: a gender-based analysis