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ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1/PPAR- signaling

HPLC methods with either UV or fluorescence detection require derivatisation of GSH prior to detection which causes further limitations driven principally as a result of enhanced susceptibility to GSH degradation and auto oxidation, instability of derivatised GSH adduct and suboptimal derivatisation conditions

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Hence, pathways and mechanisms need to be investigated for possible pharmacological intervention