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In addition, pronounced interindividual variability, influenced by external factors such as age, hyperglycemia, and gut microbiota composition, contributes to heterogeneous therapeutic responses

Cancer and cardiovascular mortality were null throughout

ROS and lipid peroxidation assay Day 12 cultured SCD erythroblasts under different treatments were incubated with 5 M 2-7-dichlorodihydrofluorescein diacetate (H2DCFDA) (#D6883, Sigma) for 30 min at 37 C, washed with PBS, and analyzed on a BD LSR-II flow cytometer for ROS level

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