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The decreased NADPH production results in insufficient reduction of oxidized glutathione disulfide (GSSG) and Prdx2, thus rendering the antioxidant system less effective ( Classes of Mutation and Spectrum of Deficiency G6PD deficiency is a heterogeneous condition with 217 mutations reported as of 2016

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IGF-1 decreases GH levels by growth hormone releasing hormone (GHRH)-dependent feedback mechanisms

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