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It is essential that clinical trials can be developed to effectively compare these routes of administration and that clinicians can share their experiences with these modalities of B12 administration so that they can be popularised and considered as viable alternatives for patients

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For instance, lactate induces M2 macrophage activation via MCT1 signaling in muscle and metabolic reprogramming in mesenchymal stem cell (MSC) secretion, promoting tissue repair and growth [103, 104]