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Thats where TRT comes in
In in vitro systems and animal studies, it has been investigated for its role in regulating cellular processes involved in extracellular matrix organization and scar-related responses under experimental conditions
The IL-4 and IL-13 inflammatory pathways have been recognized as hallmark features of AD pathogenesis, playing distinct and synergistic roles in immune dysregulation, skin barrier impairment, and key clinical manifestations such as pruritus ( Impairment of the epithelial barrier has been shown to play a key role in the pathogenesis of AD ( FLG , *135940) have been identified as the strongest genetic risk factor for AD reported to date in both European and Asian populations ( FLG gene mutations result in deficient filaggrin synthesis, disruption of the stratum corneum architecture, increased transepidermal water loss, and impaired skin hydration ( Staphylococcus aureus colonization
[DOI] [PubMed] [Google Scholar] 113.Plaza JA, Wakely PE, Jr., Suster S
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