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Multiple studies suggested that PCOS may further induce serious complications such as diabetes, hypertension, endometrial cancer (EC) and preeclampsia without timely intervention, which can severely affect the quality of life and long-term health outcomes of patients (Krentowska et al., 2021)

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3.1.2 Extrinsic pathway As its name suggests, the extrinsic pathway is triggered primarily by extracellular signals mediated by immune system cells, such as lymphocytes or macrophages