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These stresses result in the depletion of cellular antioxidants, such as glutathione

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Chang, JY, Mehran, RJ, Feng, L, Verma, V, Liao, Z, Welsh, J, Lin, SH, O'Reilly, M, Jeter, M, Balter, PA, McRae, SE, Berry, D, Heymach, JV, Roth, JA, Antonoff, MB, Hofstetter, WL, Rajaram, R, Rice, DC, Sepesi, B, Swisher, SG , Vaporciyan, AA, Walsh, GL, DeGraaf, C, Correa, AM, Chen, A, Gandhi, S, Komaki, R, Lee, PP, Nguyen, Q, Ning, M, Gao, S, Pollard-Larkin, JM, Nitsch, PL, Sadagopan, R, Wang, X

Sulforaphane-mediated KEAP1 modification releases NRF2 from degradation and results in NRF2 phosphorylation and nuclear translocation (Figure 2)

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