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Combination NRT is a patch (which is long-acting) plus a short-acting agent (like gum, lozenges, inhaler, or nasal spray), and is more effective than a single form of NRT alone

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To date, nicotine-induced changes in VTA GABAergic transmission have been shown to influence dopamine (DA) signaling and behavioral responses to alcohol and morphine (Vihavainen et al., 2008a,b