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6.2 Molecular heterogeneitydriven precision stratification Although treatment of moderate-to-severe AD has entered a new era centered on biologic agents, interindividual differences in the expression of key neuroimmune genes such as IL-31, MRGPRX2, TRPA1, NGF, and CGRP contribute to molecular heterogeneity that is closely associated with the intensity of pruritus and disease chronicity, and these differences significantly affect patients responses to therapy (187)

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