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The benzopyran-based IRAP inhibitor 37 , with high selectivity vs
The proportion of CP to CI AMPARs can differ systematically between cells of distinct types and can be different even at synapses originating from same presynaptic cells, e.g., in mossy fiber synapses to CA3 interneurons (Lei and McBain, 2002
Taking this into account, current regulations stipulate that preclinical testing should include higher drug doses than those expected to be encountered by patients [77]
That said, budget, goals, and health status do require a choice in most cases