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Clinical trial protocols titrate gradually

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For any immediate trouble breathing or swelling of the lips/tongue, call 911 or go to the nearest ER right away

The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

However, this comes with significant caveats