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PQQ can reduce blood pressure, regulate blood lipids, and delay atherosclerosis by reducing myocardial oxidative damage and improving vascular endothelial function in cooperation with coenzyme Q10

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While current clinical and basic evidence strongly supports ferroptosis as a key contributing mechanism in periodontitis progression, the extent of its role relative to classical pathogenic factors such as dysbiosis and immune dysregulation, as well as its causal temporality in the natural history of the disease, remains unclear

This method completely avoids systemic clearance barriers encountered during intravenous administration, achieving an initial colonization efficiency that is 1001000 times higher [146]