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10.1016/j.phymed.2016.02.005 34 LevinS

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Similarly, implementation of HLA-B*15:02 screening in Taiwan decreased incidence of carbamazepine-induced SJS/TEN to 0 [45]

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Moreover, these exosomes partially inhibit premature activation and depletion of primordial follicles by modulating the PI3K/AKT/mTOR signaling pathway, which is typically hyperactivated by chemotherapy, resulting in follicle burnout. Following treatment with hAEC exosomes, there is a reduction in the phosphorylation levels of critical proteins, including Akt and FoxO3a, which contributes to the preservation of ovarian reserve

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