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When residues L43, W53, and F54 were substituted with alanine, the inhibitory ability was significantly reduced, indicating that these hydrophobic residues were essential for FOXO4 FHD binding (Table 1)

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These phytochemicals have multifunctional properties such as antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, and immunomodulatory, and they act as antagonists and agonists for various types of inhibitory and excitatory receptors in the body, especially in the CNS