DN: Investigation, Software, Validation, Writing original draft, Writing review & editing
Abbasi, H., Kouchak, M., Mirveis, Z., Hajipour, F., Khodarahmi, M., Rahbar, N., et al
Healthy aging: is smaller better?a mini-review
The biofilm matrix acts as a physical barrier to block antifungal penetration, and the sessile fungal cells exhibit metabolic dormancy and upregulated expression of drug efflux pumps and target-modifying genes, and the presence of drug-resistant cells are some of the main factors leading to immune evasion and weakened response to available drugs (Sahoo et al., 2025)
This strategy suits users who plateau after several months suggesting diminishing returns, want to minimize long-term costs while maintaining some benefits, prefer avoiding indefinite commitments to any treatment, notice maintained improvements during initial breaks suggesting cycling viability, and value flexibility over maximum continuous optimization
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