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Conceptually, the dairy cow and its associated microbiota can be understood as a unified holobionta composite entity in which host and microbes co-regulate physiological homeostasis across multiple compartments 6

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showed that resveratrol exerts an anti-RA effect in vitro by activating the Nrf2/HO-1 signalling pathway, leading to the activation of Bcl-2/Bax and subsequent induction of apoptosis [144]