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Immunohistochemical (IHC) analysis showed that, in the lungs of never-smokers, there was minimal staining of p21 and p27, proteins that regulate the cell cycle and which serve as markers for cellular senescence

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RJ Reynolds and other major tobacco companies have a profit motive for supporting the amendment while taxes on their products would increase by 60 cents a pack, taxes on their off-brand competitors would increase by $1.27 a pack (the reason for this is fairly technical and involves an equity fee being assessed on certain tobacco companies due to a court settlement from the 1990s)