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check for clarity and proper refrigeration Sleep deprivation negating benefitsSemax can't fully compensate for chronic poor sleep Key Research [1]"Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus" Dolotov OV, Karpenko EA, Inozemtseva LS, et al., 2006 Finding: This study showed that a single dose of Semax increased BDNF protein levels by 40% and boosted the activation of its receptor (trkB) in the hippocampusthe brain's memory center

PMID 15781322

intracellular half-life is prolonged because of lysosomal release and cytosolic resequestration, creating a depot effect that supports monthly maintenance dosing for chronic deficiencies

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doi: 10.1016/j.tcb.2020.04.004