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PAD is estimated to affect anywhere from three to ten percent the population, but it increases to almost 20% in patients who smoke, have diabetes, or are elderly. Even secondhand smoke can contribute to your vascular health if you spend enough time around it

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Likewise, in vitro studies have shown that cigarette smoking and nicotine induce EMT by activating the Wnt/-catenin signaling pathway in HBE cells and A549 cells [116, 117]