Therefore, further experiments, designed to specifically target selected processes are required to assess the validity of mice as a model for this process in humans
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(7,12,14,16,21,23,25-27,29) Regarding the distribution of the items by factor, questions 3 and 5 are believed to belong to a single factor related to the urgency to restore nicotine levels (factor 2, designated the "Smoking Pattern" factor), whereas questions 2, 4 and 6 are thought to be part of another factor related to the pattern of consumption (factor 1, designated the "Morning Pattern" factor)
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Also, nicotine alone (10 mg/kg) led to an increase in gene expression