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Causes of coughing up blood include: Respiratory tract infection (most common cause) Chronic obstructive pulmonary disease (COPD) Smoking Inhaled (aspirated) foreign object that (usually seen in children) Cystic fibrosis Certain types of cancer Fungal infection with Aspergillus (aspergillosis) Tuberculosis Pulmonary edema Wegener's granulomatosis Inflammation of blood vessels (vasculitis) in the lung Goodpasture syndrome Granulomatosis with polyangiitis Certain drugs or chemicals Certain medical procedures Tonsillectomy Bronchoscopy Laryngoscopy Spirometry Upper airway biopsy Uncommon causes of coughing up blood that can be serious or life-threatening include: Acute bronchitis Other lung infections such as bacterial lung abscess and/or necrotizing pneumonia Immunologic lung diseases, such as anti-glomerular basement membrane (anti-GBM