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The reported RRs across studies were very heterogeneous

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Symptoms include: Anxiety or depression Cravings Difficulty concentrating Increased appetite Mood swings and irritability Poor sleep Restlessness or fidgetiness Weight gain Many patients also describe a significant emotional loss, similar to ending a relationship, when trying to quit smoking

Looking at that list, however, you need to visualize that all of those components have raw materials harvested somewhere, a manufacturing process where chemicals are combined to make compounds, frequently with external thermal requirements to achieve a certain temperature