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Therefore, metabolomics has been widely applied in various fields, such as drug toxicity, disease diagnosis, and pharmacodynamic study [40,41,42]

DOI: 10.1001/jamanetworkopen.2022.0951 The study was supported by grant P30 CA14599 from the University of Chicago Medicine Comprehensive Cancer Center, the Global Research Award for Nicotine Dependence from Pfizer and the Womens Board of the University of Chicago Cancer Research Foundation

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