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found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells

Tuy nhin vi ngi cao tui hoc nhng ngi mc bnh l v gan, lng Glutathion s b suy gim khin mt s chc nng trong c th v l gan b nh hng

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The medium was concentrated using 0.5 mL Amicon Ultra 10 kDa molecular weight cut-off filters (Millipore, Ireland), in accordance with the manufacturers instructions

Camfield DA, Sarris J, Berk M