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This activation increases the expression of downstream HO1 and NQO1 , inhibits the expression and secretion of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH), and improves the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)