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This is why combining the two pathways produces additive effects

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Beyond the pancreas, GLP-1 receptors are expressed in the liver, adipose tissue, kidneys, and hypothalamus, which accounts for the drug class's broader effects on satiety, weight, inflammation, and renal protection.[4] The relevance to PCOS is direct: by improving insulin sensitivity and reducing hyperinsulinemia, GLP-1 receptor agonists lower the primary driver of ovarian androgen overproduction