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In 2017, new FDA commissioner Scott Gottlieb, an advocate of e-cigarettes as an alternative to combustible ones, delayed those requirements, giving manufacturers until August 2022 to submit so-called marketing applications

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This primary brain injury can be attributed to the activation of secondary injury pathways that include ionic imbalance, oxidative stress, excitotoxicity, mitochondrial dysfunction, inflammation, and BBB breakdown (Dirnagl et al., 1999