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According to the American Cancer Society, trouble sleeping is a common side effect of Zyban (bupropion)

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Chemicals in Cigarettes and Cigarette Tobacco The harmful chemicals in cigarette smoke can damage nearly every organ in the body

At the end of the experiment, animals were anesthetized by intraperitoneal injection of ketamine (80 mg/kg) and xylazine (10 mg/kg) until total reflex loss was obtained, ensuring profound anesthesia