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For example, antibiotics speed up the metabolism, resulting in the nicotine flushing out of the system quicker

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Nicotine also binds 42, a high-affinity receptor along GABA neurons, which, with chronic nicotine use, become desensitized, therefore dampening the inhibition on dopaminergic transmission from the VTA to the NAc, while 7, low-affinity nAChRs on glutamatergic neurons are less prone to desensitization, therefore continue to enhance dopamine transmission (94, 95)

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Health-care professionals should increase patients awareness of the hazards of smoking and provide smoking cessation advice to enhance their self-efficacy in quitting [122, 123]