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We excluded some meta-analyses from Cochrane reviews (e.g., bupropion, NRT) because they included some RCTs with active controls, and we applied a strict placebo or usual care control criterion

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This could be hypothesized to be either due to effects of having epilepsy such as increased rates of comorbid mental illness, social factors such as lower socioeconomic status, or due a shared diathesis for addictive behavior and seizures due to the behavior of pathological neural networks in the brain

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